Posts Tagged ‘Animal-Human Hybrids’

Japanese Scientist Obtains Permission for Animal-Human Hybrids

August 1, 2019

This is very ominous. A Japanese scientist has been granted permission to create animal-human hybrids, according to yesterday’s I. The man intends to use them in research for the possible creation of organs in animals, that could be used for transplantation into humans. There are limits to his research, however. He states that at the moment he will not keep them alive for longer than 15 and a half days, so it isn’t like he’s going to produce complete animal-human hybrids, like the chimpanzee-human creature developed by rogue scientists as a new slave animal in the 1990s ITV SF thriller, Chimera. But it is a step in that direction.

The article, ‘Human-animal hybrid research is approved’, by Colin Drury, on page 22, runs

Human-animal hybrids are to be developed in embryo form in Japan after the government approved controversial stem-cell research.

Human cells will be grown in rat and mouse embryos, then brought to term in a surrogate animal, as part of experiments to be carried out at the University of Tokyo.

Supporters say the work – led by the renowned geneticist Hiromitsu Nakauchi – could be a vital first step towards eventually growing organs that can then be transplanted into people in need.

But opponents have raised concerns that scientists are playing God. Critics worry the human cells could stray beyond the targeted organs into other areas of the animal, creating a creature that is part animal, part person.

For that reason, such prolonged experimentation has been banned or not been financed across the world in recent years.

In Japan, scientists were forbidden from going beyond a 14-day growth period. But those laws were relaxed in March when the country’s education and science ministry issued new guidelines saying such creations could now be brought to term.

Now, Dr. Nakauchi’s application to experiment is the first to be approved under that new framework.

Human-animal hybrid embryos have been made in countries such as the United States, but were never brought to term. The US National Institutes of Health has had a moratorium on funding such work since 2015.

“We don’t expect to create human organs immediately, but this allows us to advance our research based upon the know-how we have gained up to this point,” Dr. Nakauchi told the Asahi Shimbun newspaper.

He added that he planned to proceed slowly, and will not attempt to bring any hybrid embryos to term for several years, rather growing the hybrid mouse embhryos to 14.5 days, when the animal’s organs are mostly formed, and the hybrid rat embryo’s to 15.5 days.

Such caution was welcomed by bioethicists in the country.

There was also a little capsule, containing the comment that

Some bioethicists are concerned about the possibility that human cells might stray, travelling to the developing animal’s brain and potentially altering its cognition.

Which seems to be a concern that this research could unintentionally also result in animals acquiring some form of human intelligence accidentally.

The British philosopher Mary Midgley attacked that part of the biotech industry and those scientists, who looked forward to bioengineers being able to redesign whole new forms of humans in her book, The Myths We Live By (London: Routledge 2004). She writes

That ideology is what really disturbs me, and I think it is what disturbs the public. This proposed new way of looking at nature is not scientific. It is not something that biology has shown to be necessary. Far from that, it is scientifically muddled. It rests on bad genetics and dubious evolutionary biology. Though it uses science, it is not itself a piece of science but a powerful myth expressing a determination to put ourselves  in a relation of control to the non-human world around us, to be in the driving seat at all costs rather than attending to that world and trying to understand how it works. It is a myth that repeats, in a grotesquely simple sense, Marx’s rather rash suggestion that the important thing is not to understand the world, but to change it. Its imagery is a Brocken spectre, a huge shadow projected on to a cloudy background by the shape of a few recent technological achievements.

The debate then is not between Feeling, in the blue corner, objecting to the new developments, and Reason in the red corner, defending them. Rhetoric such as that of Stock and Sinsheimer and Eisner is not addressed to Reason. It is itself an exuberant power fantasy, very much like the songs sung in the 1950s during the brief period of belief in an atomic free lunch, and also like those in the early days of artificial intelligence. The euphoria is the same. It is, of course, also motivated by the same hope of attracting grant money, just as the earlier alchemists needed to persuade powerful persons tthat they were going to produce real, coinable gold. (p. 166).

She goes on to argue that such scientific hubris comes from the gradual advance of atheism with the victory of the mechanistic model of the universe introduced by Newton in the 17th century. As God receded, scientists have stepped in to take His place.

On the clockwork model the world thus became amazingly intelligible. God, however, gradually withdrew from the scene, leaving a rather unsettling imaginative vacuum. The imagery of machinery survived. But where there is no designer the whole idea of mechanism begins to grow incoherent. Natural Selection is supposed to fill the gap, but it is a thin idea, not very satisfying to the imagination.

That is how the gap that hopeful biotechnicians now elect themselves to fill arose. They see that mechanistic thinking calls for a designer, and they feel well qualified to volunteer for that vacant position. Their confidence about this stands out clearly from the words I have emphasised in Sinsheimer’s proposal that ‘the horizons of the new eugenics are in principle boundless – for we should have the potential to create new genes and new qualities yet undreamed of … For the first time in all time a living creature understands its origin and can undertake to design its future.’

Which living creature? It cannot be human beings in general, they wouldn’t know how to do it. It has to be the elite, the biotechnologists who are the only people able to make these changes. So it emerges that members of the public who complain that biotechnological projects involve playing God have in fact understood this claim correctly. That phrase, which defenders of the projects dismiss as mere mumbo jumbo, is actually a quite exact term for the sort of claim to omniscience and omnipotence on these matters that is being put forward.

One of the most profound artistic comments I have found about the implications of this new biotechnology is the sculpture ‘The Young Family’ by the Australian artist Patricia Piccinini. This shows a hybrid mother creature, bred for organ transplantation, surrounded by her young. Curled up like an animal, her human eyes peer back plaintively at the spectator. It’s a deeply disturbing work, although Piccinini states she is not opposed but optimistic about scientific progress. She says

In terms of the real world, these are some of the key issues that I am trying to question and discuss with my work. I’m not pessimistic about developments in biotechnology. We are living in a great time with a lot of opportunities, but opportunities don’t always turn out for the best. I just think we should discuss the full implications of these opportunities.

So if we look at The Young Family we see a mother creature with her babies. Her facial expression is very thoughtful. I imagine this creature to be bred for organ transplants. At the moment we are trying to do such a thing with pigs, so I gave her some pig-like features. That is the purpose humanity has chosen for her. Yet she has children of her own that she nurtures and loves. That is a side-effect beyond our control, as there will always be.

That is what makes the question of breeding animals purely for organ-transfer so difficult to answer. On one hand we need organs to help people in need, on the other hand we are looking at an animal that wants to exist for the sake of itself. I can’t help but feel an enormous empathy for this creature. And, to be very honest, if it would save the life of one of my children, I would be will to take one of these organs. I know it is probably not ethically right but sometimes honesty, emotions, empathy and ethics don’t always line up.

I am not nearly so optimistic. For me, this sculpture is a deeply moving, deeply disturbing comment on the direction this new technology can go. And I fear tht this latest advance is taking us there.

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